LYMPHOID NEOPLASIA RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia
نویسندگان
چکیده
1Cancer Research UK Children’s Cancer Group, Manchester Academic Health Science Centre, School of Cancer & Enabling Sciences, University of Manchester, Manchester, United Kingdom; 2Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom; 3Mass Spectrometry Service, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom; 4Stem Cell and Leukemia Proteomics Laboratory, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; 5Applied Computational Biology and Bioinformatics Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom; 6Histology Service, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom; 7Flow Cytometry Service, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom; 8Advanced Imaging, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom; and 9Department of Paediatric and Adolescent Oncology, Royal Manchester Children’s Hospital, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester, United Kingdom
منابع مشابه
Face Bones Involvement and Relapse in a Case of Childhood Acute Leukemia
Midface bones are an unusual site for primary presentation and relapse in acute lymphoblastic leukemia. Herein, we describe a case of acute pre B cell lymphoblastic leukemia with leukemic infiltration of maxilla and bone marrow involvement. At the time of relapse, the patient presented again with maxilla involvement and the phenotype changed to biphenotypic lymphoblastic leukemia. Our case sug...
متن کاملEpigenetic effects of decitabine on acute lymphoblastic and acute promyelocytic leukemia cells
Background: Decitabine (5-aza-2'-deoxycytidine, DAC) is a deoxycytidine analog currently used as an effective drug against myelodysplastic syndromes and acute myeloid leukemia. Although various studies have pointed out the epigenetic effects of this drug, its epigenetic mechanisms in different leukemic cell lines are not specified. In this lab trial study, possible epigenetic effects of decitab...
متن کاملCharacterization of Immunophenotypic Aberrancies in Adult and Childhood Acute Lymphoblastic Leukemia: Lessons from Regional Variation
Background & Objective: Although the antigen expression patterns of acute lymphoblastic leukemia (ALL) are well known, this study attempted to evaluate commonly used immune markers for immunophenotyping of acute leukemia to set the minimum of necessary diagnostic panels by flow cytometry. Methods: This study evaluated 89 patients referred from all over th...
متن کاملa case of acute leukemia with multiple complications due to leukemia and it\'s treatment: case report
Background: Acute leukemia is one of the most common types of childhood malignancies and one fourth of malignancies in this age group is acute leukemia. Acute leukemia may be myeloid or lymphoid. Acute lymphoblastic leukemia is characterized with abnormal proliferation of lymphoid cells and symptoms related to this are acute and if disease is not treated appropriately, it progresses rapidly and...
متن کاملImmunophenotyping of childhood acute lymphoblastic leukemia in Qazvin; A cross-sectional study
Background: Acute Lymphoblastic Leukemia (ALL) is the most prevalent cancer in childhood. ALL is a heterogeneous type of malignancy and treatment protocols vary based on the immunological classification of ALL. The critical step for treating ALL is immunological subgroup identification by flow cytometry findings. In this study, for the first time, immunophenotypic information was evaluated in c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011